• br Autophagy in the central nervous

  2023-10-23

  

  Autophagy in the central nervous system The autophagic process appears to be very important for the cells of the central nervous system, as it allows to maintain the functional integrity of the nervous tissue. Indeed macroautophagy is involved in the regulation of homeostasis of the CNS, playing

• Polyphenols like flavonoids have the potential to penetrate

  2023-10-23

  

  Polyphenols like flavonoids have the potential to penetrate into lipid bilayers which is vital for enabling protection against oxidation. Rosmarinic nk1 receptor antagonist is a natural polyphenol antioxidant isolated from Sphaeranthus amaranthoides. Polyphenols can inhibit the propagation of lipid

• Receptor Subtypes and Their Function Critical Appraisal Larg

  2023-10-23

  

  Receptor Subtypes and Their Function – Critical Appraisal Largely unselective ligands of the benzodiazepine binding site, such as diazepam, are known to elicit a wide range of in vivo effects including hypnosis, sedation, anxiolysis, and muscle relaxation. Genetically modified mice were introduced

• The renin angiotensin system RAS

  2023-10-23

  

  The renin-angiotensin system (RAS) is a hormonal system which plays a role in the regulation of blood pressure and body fluid comt inhibitor [14]. The main bioactive peptide of RAS is angiotensin II (Ang II) whose biological functions are interposed through angiotensin type 1 receptor (AT1R) and an

• br Androgen interference with the action of arachidonic

  2023-10-23

  

  Androgen interference with the action of arachidonic recombinant insulin mg metabolites’ actions; the other side of the coin Arachidonic acid, being a polyunsaturated fatty acid present in the phospholipids of the membrane of cells, is highly abundant within the organism. It is mainly involved i

• As an internal control this

  2023-10-23

  

  As an internal control, this study validated many of the known associations between GATA3 and predictive markers. GATA3 was shown to be associated with ER and PR, which are both well-known correlations. GATA3 was also negatively correlated with nuclear grade, which is consistent with our knowledge o

• br Acknowledgments br Introduction Alzheimer s disease

  2023-10-23

  

  Acknowledgments Introduction Alzheimer's disease (AD) is a severe neurodegenerative disorder primarily affecting the elderly population. Senile plaques in the brain, one of the pathological hallmarks of AD, are formed by the accumulation of aggregated β-amyloid (Aβ) with an extensive β-sheet s

• INDY Evidence shows that glial activation

  2023-10-23

  

  Evidence shows that glial activation increases the expression of cytokines and chemokines in Parkinson's disease, which precede the degeneration of the substance nigra (Halliday and Stevens, 2011, Tansey and Goldberg, 2010). The use of non-steroidal anti-inflammatory drugs (except aspirin) can preve

• Furthermore stress hormones can indirectly induce DNA damage

  2023-10-23

  

  Furthermore, stress hormones can indirectly induce DNA damage, for example by altering DNA repair and transcriptional regulation of the cell cycle. It has been found that stress hormones induce the up-regulation of checkpoint kinase 1 (Chk1) and checkpoint kinase 2 (Chk2) and proto-oncogene cell div

• It is worth mentioning that

  2023-10-23

  

  It is worth mentioning that cordycepin, as an adenosine analogue, is structurally similar to adenosine. A previous study has shown that the anti-apoptotic effects of cordycepin are partially dependent on the activation of A1R [16], and cordycepin increases theta waves power density via nonspecific a

• The potential use of derivatives belonging to this series

  2023-10-23

  

  The potential use of derivatives belonging to this series as therapeutic agents mostly depends on their pharmacokinetics and pharmacodynamics. The pharmacokinetic phase includes absorption, distribution, metabolism and excretion (ADME) of the studied compounds. Therefore, preliminary data for theore

• br Experimental section br Results and

  2023-10-21

  

  Experimental section Results and discussion Conclusion In the present study, 3a,8a-dihydroxy-8-oxo-1,3,3a,8a-tetrahydroindeno[1,2-d]imidazol-2(1H)-iminium chloride (3) has been synthesized and characterized by spectral studies and single crystal X-ray crystallography. DFT calculations have

• In conclusion AXL overexpression preexisted

  2023-10-21

  

  In conclusion, AXL overexpression preexisted in a subgroup of treatment-naive lung adenocarcinoma specimens harboring an activating EGFR mutation or in those with wild-type EGFR. Anti-AXL therapeutics delivered up front in combination with the EGFR inhibitor might overcome intrinsic or acquired resi

• Another important question concerns the mechanism by

  2023-10-21

  

  Another important question concerns the mechanism by which a polyubiquitinated substrate is released from the Cdc48 complex and passed on to downstream components, such as the proteasome. There are at least three proposed models. In the first, a ubiquitinated substrate is transferred by ubiquitin-bi

• Telotristat Loss of expression or functional activity of cel

  2023-10-21

  

  Loss of expression or functional activity of cell adhesion is intricately related to advanced stages of tumour progression and invasiveness. Martin-Belmonte and Perez-Moreno recently mentioned that the deregulation of adhesion can alter tumourgenesis in the early stage. We have shown for the first t

14334 records 211/956 page Previous Next First page 上5页 211212213214215 下5页 Last page