• rxr receptor In the liver ghrelin has opposite effects to in

  2022-06-17

  

  In the liver, ghrelin has opposite effects to insulin on the expression of the enzyme PEPCK, thereby promoting gluconeogenesis and also causing a decrease in glucose uptake and fatty rxr receptor oxidation (Rigault et al., 2007). Ghrelin also stimulates hepatic lipogenesis de novo in a GH-independe

• It has also been demonstrated that PS is ubiquitinated

  2022-06-17

  

  It has also been demonstrated that PS1 is ubiquitinated by Caenorhabditis elegans SEL-10 [52], Fbw7 the mammalian homologue of SEL-10 [38], and more recently by tumour necrosis factor farnesyl diphosphate synthase associated factor 6 (TRAF6), which facilitates Lysine-63 (K63)-linked polyubiquitinati

• br Introduction Fructose bisphosphatase FBPase EC catalyses

  2022-06-17

  

  Introduction Fructose 1,6-bisphosphatase (FBPase; EC 3.1.3.11) catalyses the irreversible reaction of hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate [1]. Genetic and kinetic studies so far have demonstrated that at least two distinct isoenzymes of FBPase e

• We addressed the role of

  2022-06-16

  

  We addressed the role of GSNOR-mediated T-cell activation in HHcy-accelerated atherosclerosis in vivo by two mouse models. Generated for the first time, GSNOR-/-ApoE-/- double knock-out mice showed decreased atherosclerosis in aortic roots in response to HHcy. The specificity of GSNOR ablation in T

• The Berlin patient is a unique case and dependent

  2022-06-16

  

  The Berlin patient is a unique case and dependent on the histocompatibility-matched CCR5Δ32/Δ32 homozygous donors. These donors occur at a little higher rate in the European Caucasian population, but they are very rare in Asians and Africans.15, 16, 17 The recently developed genome-editing technolog

• Obestatin synthetized mainly in the

  2022-06-16

  

  Obestatin, synthetized mainly in the gastrointestinal tract, participates in the regulation of metabolic functioning at both central and peripheral levels (food intake, pancreatic activity or/and adipocytes proliferation) (Granata et al., 2008; Li et al., 2011). It is involved in the complex gut-bra

• A high throughput screening campaign

  2022-06-16

  

  A high-throughput screening campaign of the Lilly corporate compound collection led to the discovery of as potent and selective inhibitor of GlyT1 (IC=45nM, GlyT2 IC>30,000nM). In addition to the characteristic -methyl glycine moiety as acidic head group and the novel ethanolamine linker, also co

• br Endogenous lipids as SLC

  2022-06-16

  

  Endogenous lipids as SLC6 transporter modulators Lipids constitute part of the environment in which membrane-embedded transporters operate [62]. Endogenous lipids can act as inhibitory ligands [63] or functionally important components of the membrane that impart changes in transporter structure [

• br Results br Discussion Using

  2022-06-16

  

  Results Discussion Using a novel viral vector for norepinephrine-targeted gene deletion, we have shown that glucocorticoid receptor WP 1130 synthesis from locus coeruleus norepinephrine neurons reduces social interaction specifically in female mice. This effect is not attributable to changes

• MAPK are involved in a large variety of solid and

  2022-06-15

  

  MAPK are involved in a large variety of solid and hematolgical neoplasms and, indeed, several components of the MAPK network have already been proposed as targets in cancer therapy, such as p38, JNK, ERK1/2, MEK1/2, RAF, RAS, DUSP1 and ERK5 [11], [12]. Among them, alteration of the RAS-RAF-MEK1/2-ER

• When tested in dog at mg kg showed a

  2022-06-15

  

  When tested in dog at 20mg/kg, showed a reduction of 56% of Aβ42 in the cerebrospinal fluid (CSF) 8h post doing, comparable to that of (see ). Upon evaluation of c-di-AMP in a one week repeated dose study in dog, at 10 and 20mg/kg/day, no increase in liver enzyme levels (ALT or AST) was observed

• NVS-CRF38 The diverse biochemistry of zinc means

  2022-06-15

  

  The diverse biochemistry of zinc means that, in many cases, more than one factor (or pathway) is at play. Whilst catalytic Zn2+ sites are now typically well-understood, the recognition that Zn2+ levels regulate the function of many cell types has led to vigorous interest in the fate and role of mobi

• It is noted that knee swelling was milder and

  2022-06-15

  

  It is noted that knee swelling was milder and the intensity of IL-4 staining (MFI) in the vehicle-treated group was lower in the second (Fig. 7a and d) than the first (Figs. 1a and 3f) AIA experiment. The variation in joint swelling between the two studies is most likely due to the models being perf

• Attractively existing reports suggest that

  2022-06-15

  

  Attractively, existing reports suggest that cellular ferroptosis also probably plays vital role in liver fibrosis [[62], [63], [64]]. Carlson BA et al. illuminated that the ferroptosis regulator GPX4 was important for hepatocyte survival and proper liver function [62]. Sun X et al. showed that Nrf2

• br Clinical assessment of iron chelation br Towards the

  2022-06-15

  

  Clinical assessment of iron chelation Towards the new concept of conservative iron chelation: iron scavenging and redeployment For any chelator to be of clinical value in disorders of regional siderosis they ought to be endowed with a requisite accessibility to the relevant sites and different

14335 records 392/956 page Previous Next First page 上5页 391392393394395 下5页 Last page