• The best preserved individuals were selected for isotope ana

  2020-02-17

  

  The best preserved individuals were selected for isotope analysis of diet (Table 2). These represent 21 individuals including four subadults: two young children aged between 1.5 and 2.5 years old, one child between 7 and 11 years old and one adolescent (12–16 years old), and 17 adults including six

• br These component origins have been

  2020-02-17

  

  These component origins have been chosen as they potassium channel are well-defined options related to developing with components (see for example Morisio and Torchiano (2002); Carney and Long (2000) and Gacek and Arief (2004)). The individual component origins (COTS, OSS, in-house developed com

• It should be noted that not

  2020-02-17

  

  It should be noted that not only glyphosate but E2 at the same concentration range (10−11-10−7 M) also showed similar effects on the expression of the secretin receptor regulating proteins. Furthermore, we could not see a significant difference among this concentration range of glyphosate and E2 on

• Given its high frequency it is not surprising that different

  2020-02-17

  

  Given its high frequency, it is not surprising that different strategies have been developed to restore the sensitivity of EGFR T790M-mutant Ac-IETD-pNA to EGFR inhibition. To date, several different strategies have been evaluated in both preclinical and clinical models, but only few have been prov

• This project was funded by

  2020-02-14

  

  This project was funded by the Deutsche Forschungsgemeinschaft within FOR 2251 (project grants EB 285/2-1 and WI 3272/3-1) and in part by additional contributions from the Bundesministerium für Bildung und Forschung (D.I.S award Nos. BIOSCAT [05K12YE1]) and the Horizon 2020 programme of the European

• Other factors also contribute to replication fork progressio

  2020-02-14

  

  Other factors also contribute to replication fork progression in DNA damage conditions. For instance, the cullin Rtt101 has a role in fork movement through alkylated DNA, probably associated to a damage tolerance mechanism [52], and TORC signaling is also important for fork progression in response t

• Our results suggest that formation of DDR b clusters

  2020-02-14

  

  Our results suggest that formation of DDR1b clusters may be important for and precede receptor phosphorylation. Indeed, while DDR1b clustering was readily detected (by YFP signal) 30 min after collagen administration, phosphorylated DDR1 species at Y513 (present in the IJXM) were evident after 4 h o

• YK-4-279 Recent studies have shown arsenic could cause

  2020-02-14

  

  Recent studies have shown arsenic could cause autophagic cell death in malignant cells, including leukemia and malignant glioma YK-4-279 [16], [17]. However, at present, little is known about the consequences of arsenic-treated urothelial cells in autophagy and expression of its related proteins. T

• Although the crystal structures of Atg C and

  2020-02-14

  

  Although the crystal structures of Atg4C and Atg4D are not available, their three dimensional structures can be acquired by homology modeling, using the structure of Atg4B as a template (Zhang, Li, Ouyang, Liu, & Cheng, 2016). In that model, the catalytic triad is conserved (Cys110/Asp345/His347 for

• br Experimental procedures br Introduction Perfluorooctane s

  2020-02-14

  

  Experimental procedures Introduction Perfluorooctane sulfonate (PFOS) is an anthropogenic compound with high thermal, chemical and biological stability, which makes it a perfect ingredient for many industrial applications (Kissa, 2001). Nevertheless, these characteristics also mean that PFOS i

• ack1 inhibitor The inhibition of FAS by

  2020-02-14

  

  The inhibition of FAS by C75 produces an accumulation of malonyl-CoA which is difficult to reconcile with the activation of CPT1 reported by others [2], [16], [17], [18]. To unravel this paradox the mechanism of action of C75 needs to be examined. We recently demonstrated that C75 is converted in vi

• AZD 7762 From our array results Supplemental Fig S we found

  2020-02-14

  

  From our array results (Supplemental Fig. S2), we found that differential lncRNA profiling exhibited much greater disparity compared to differential gene profiling in CD28nullCD8+ T cells, indicating that differentially expressed lncRNA(s) would serve as ideal hallmarks. Moreover, we were fortunate

• A more refined picture of cholinesterase activity patterns

  2020-02-14

  

  A more refined picture of cholinesterase activity patterns may be obtained by measuring ChE activity of the same sample before and after addition of certain cholinesterase inhibitors, with differential specificity for different components of total ChE activity, such as BW284c51 (BW1,5-bis-(4-allyldi

• br Agonist binding ETA activation is

  2020-02-14

  

  Agonist binding ETA activation is promoted by binding of the endogenous peptidergic agonists to their orthosteric binding site on the receptor. ET1 and ET2 (Trp6-Leu7-ET1) bind with equal high affinity to ETA, whereas the third endogenous isopeptide ET3 (Thr2-Phe4-Thr5-Tyr6-Lys7-Tyr14-ET1) binds

• There is a functional ubiquitin

  2020-02-14

  

  There is a functional ubiquitin association (UBA) domain at the N terminus of MCPIP1. Liang et al. have discovered that MCPIP1 may be a deubiquitinase and defined a novel DUB domain of MCPIP1 [22]. Ubiquitin and deubiquitin modification emerge as the key mechanisms that regulate the virus-induced ty

14387 records 854/960 page Previous Next First page 上5页 851852853854855 下5页 Last page